Can Medication Ease Insomnia in Veterans with PTSD?

LAST UPDATED: March 25, 2022
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Source: Vantage Point​​​External Link
​Author: Mike Richman​​

Can medication ease insomnia in Veterans with PTSD? VA study aims to find out ​
​Some patients with PTSD find advantages to starting treatment with psychotherapies, such as cognitive processing therapy, or self-care approaches, such as meditation, yoga, and exercise. However, for many people, insomnia and other severe symptoms must be urgently treated because of the distress and impairment that they cause. In such cases, it may be impractical to withhold medication for the time needed to test alternatives.

So says Dr. John Krystal, a psychiatrist with VA's National Center for PTSD. He has co-authored studies that have examined the efficacy of drugs for Veterans with chronic military-related PTSD.

Currently, Krystal is leading a study that is comparing three FDA-approved drugs for their ability to treat Veterans with PTSD who have insomnia, one of the most common and hardest-to-treat symptoms for patients with that mental health condition. While there are no FDA-approved drugs for treating insomnia in this population, he says, physicians often prescribe FDA-approved medications for other clinical applications to patients with PTSD-related insomnia. These are called “off-label" prescriptions.

“Most of the Veterans in our study have suffered from PTSD and insomnia symptoms for several years," says Krystal, who is also affiliated with the VA Connecticut Healthcare System and the Yale School of Medicine. “These Veterans continue to have symptoms despite treatments with psychotherapy and medications. It turns out that insomnia is one of the most persistent symptoms associated with PTSD, and it often fails to respond to both of the FDA-approved drugs for PTSD – sertraline and paroxetine."

Three drugs in trial have different applications

In a double-blind tr​ial, Krystal and his team will compare the drugs trazodone, eszopiclone and gabapentin to placebo. All three contain sleep-inducing ingredients but work in different ways. Trazodone is approved for treating depression and eszopiclone for treating insomnia. Gabapentin, an epilepsy medication, is also prescribed for such conditions as migraine headaches, pain and mood disorders.

The researchers are aiming to recruit 1,224 Veterans from about 30 VA medical centers. The participants must have PTSD and at least moderate levels of insomnia as measured at baseline according to the Insomnia Severity Index (ISI), a questionnaire designed to assess the severity of insomnia.

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